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Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 508-511 doi: 10.1007/s11684-015-0418-7

Abstract:

Bile duct injury is a common complication of cholecystectomy.The timing of bile duct injury repair remains controversial.Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommendedPercutaneous drainage of bile and endoscopic stenting are the mainstays of treatment of bile leak becausethey convert acute bile duct injury into a controlled external biliary fistula.

Keywords： bile duct injury     cholecystectomy     laparoscopic cholecystectomy    

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Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones

Zongming Zhang, Zhuo Liu, Limin Liu, Mengmeng Song, Chong Zhang, Hongwei Yu, Baijiang Wan, Mingwen Zhu, Zixu Liu, Hai Deng, Haiming Yuan, Haiyan Yang, Wenping Wei, Yue Zhao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 576-589 doi: 10.1007/s11684-017-0536-5

Abstract: duct stones by combining our practical experience were summarized as follows. (1) For intrahepatic bileduct stones, the operation may be selected by laparoscopic liver resection, laparoscopic common bileand common bile duct stones, the surgical approach can be selected as follows: laparoscopic cholecystectomyand extrahepatic bile duct stones, laparoscopic liver resection, choledochoscopy through the hepaticduct stones.

Keywords： laparoscopy     choledochoscopy     duodenoscopy     cholelithiasis     minimally invasive treatment    

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Effects of hydralazine and valproate on the expression of E-cadherin gene and the invasiveness of QBC

Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 153-157 doi: 10.1007/s11684-009-0034-5

Abstract: To clarify the effect of DNA methylation and histone deacetylase inhibitors on the expression of the E-cadherin gene and the invasiveness of the QBC cells, the QBC cells were separately treated with hydralazine, valproate, or combination of the two drugs. The mRNA expression of E-cadherin was examined with reverse transcription-polymerase chain reaction (RT-PCR), the protein of the gene with Western blotting. The methylation status of the promoter region of the gene was detected with methylation-specific PCR (MSP). The invasiveness of QBC cells was detected with transwell assay. It was found that the promoter region of the E-cadherin gene of QBC cells was hypermethylated. Valproate alone could not contribute to demethylation of the gene, whereas hydralazine could make them to be partly demethylated. However, the methylation status of the gene could be thoroughly reversed by using valproate and hydralazine in combination. What’s more, it was confirmed that the E-cadherin gene of QBC cells could not be transcriptionally reactivated by Valproate alone, whereas hydralazine alone could induce moderate reexpression of the gene. However, using valproate and hydralazine in combination could result in robust reexpression of the E-cadherin gene ( =0.000). Likewise, the invasiveness of the QBC939 cells was sharply decreased by treatment with two drugs in combination and slightly decreased with one drug alone. It could be concluded that the two drugs have synergistic effect on the demethylation and reexpression of the E-cadherin gene of QBC cells, and also on the reduction of the invasiveness of the QBC939 cells.

Keywords： DNA methylation inhibitor     histone deacetylase inhibitor     bile duct carcinoma     E-cadherin    

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A giant Müllerian duct cyst in the perineum: a case report

Xianghu Meng, Jihong Liu, Xiao Yu, Shaogang Wang, Cong Liu, Zhangqun Ye

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 440-443 doi: 10.1007/s11684-012-0222-6

Abstract:

The authors present a case report of a giant Müllerian duct cyst in the perineum.Pathologic examination confirmed the presence of a Müllerian duct cyst.Huge Müllerian duct cyst is uncommon in clinic.Treatments of Müllerian duct cysts depend on their sizes and symptoms.

Keywords： Müllerian duct cyst     clinical symptoms     diagnosis    

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Bile acids and their effects on diabetes

Cynthia Rajani, Wei Jia

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 608-623 doi: 10.1007/s11684-018-0644-x

Abstract: Manipulation of bile acid (BA) receptors and the BA pool have been shown to be useful in establishing

Keywords： bile acids     metabolic memory     diabetes     circadian rhythm     bariatric surgery    

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Diagnosis and treatment of thyroglossal duct carcinoma: Report of three cases with review of literatures

GAO Yan, CHEN Yan, SUN Zhipeng, GUO Chuanbin, YU Guangyan, ZHAN Yi

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 58-62 doi: 10.1007/s11684-008-0011-4

Abstract: Thyroglossal duct carcinoma, which is usually diagnosed postoperatively, is a rare malignant tumor arisingin the thyroglossal duct cyst.We retrospectively reviewed three cases of thyroglossal duct carcinoma diagnosed in Peking UniversityThe constituent ratio of thyroglossal duct carcinoma among surgically excised thyroglossal duct lesionsTwo cases were diagnosed as thyroglossal duct cyst prior to the operation, the remaining one as dermoid
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Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 887-902 doi: 10.1007/s11684-021-0879-9

Abstract: Subarachnoid hemorrhage (SAH) induces white matter injury, but the involvement of MCT1 is unclear.the SAH model of adult male Sprague-Dawley rats was used to explore the role of MCT1 in white matter injury

Keywords： microRNAs     monocarboxylate transporter 1     motor training     subarachnoid hemorrhage     white matter injury    

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Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 393-402 doi: 10.1007/s11684-017-0532-9

Abstract:

The risk factors, especially laboratory indicators, of prognosis after acute kidney injury (AKI) remain

Keywords： acute kidney injury     risk factors     prognosis    

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Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 197-205 doi: 10.15302/J-FASE-2018245

Abstract: Taken together, our results demonstrated that leonurine attenuated brain injury during ischemia via antioxidative

Keywords： cerebral ischemia     GABA     neuroprotection     leonurine     SOD    

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Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare

Yong Li,Yuhong Huang,Nan Feng,Heping Zhang,Jing Qu,Shuanggang Ma,Yunbao Liu,Jiang Li,Shaofeng Xu,Ling Wang,Mi Zhang,Jie Cai,Weiping Wang,Ru Feng,Hang Yu,Bo Yu,Dailiang Liang,Heping Qin,Suxiang Luo,Yanfen Li,

Engineering doi: 10.1016/j.eng.2023.09.017

Abstract: Bear bile has been a valuable and effective medicinal material in traditional Chinese medicine (TCM)Here, we present a new approach for creating artificial bear bile (ABB) as a high-quality and sustainablealternative to natural bear bile.This study addresses the scientific challenges of creating bear bile alternatives through interdisciplinarytechnologies, our research has achieved the environmentally friendly, large-scale production of bear bile

Keywords： Artificial bear bile     Chemical profile     Formula optimization     Pharmacodynamic consistency     Preclinical toxicological    

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Progress and perspectives of neural tissue engineering

Xiaosong Gu

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 401-411 doi: 10.1007/s11684-015-0415-x

Abstract:

Traumatic injuries to the nervous system lead to a common clinical problem with a quite high incidence and affect the patient’s quality of life. Based on a major challenge not yet addressed by current therapeutic interventions for these diseases, a novel promising field of neural tissue engineering has emerged, grown, and attracted increasing interest. This review provides a brief summary of the recent progress in the field, especially in combination with the research experience of the author’s group. Several important aspects related to tissue engineered nerves, including the theory on their construction, translation into the clinic, improvements in fabrication technologies, and the formation of a regenerative environment, are delineated and discussed. Furthermore, potential research directions for the future development of neural tissue engineering are suggested.

Keywords： nerve injury     tissue engineering     nerve grafts    

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Protective effect of N-acetylcysteine against lipopolysaccharide injury in hepatocytes of neonatal mice

WANG Lin, LIU Yalan, XU Jianbo, TIAN Yuan, WU Heshui

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 182-185 doi: 10.1007/s11684-008-0034-x

Abstract: evidence for the effective prevention and treatment of lipopolysaccharide (LPS)-induced hepatocyte injuryNAC has protective effects in hepatocytes of neonatal mice against LPS-induced injury as shown by the
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Effect of oxytocin on gastric ischemia-reperfusion injury in rats

ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 433-437 doi: 10.1007/s11684-007-0085-4

Abstract: The effect of peripherally administered oxytocin (OT) on gastric ischemia-reperfusion injury (GI-RI)These results indicated that the oxytocin could significantly protect gastric mucosal against injury

Keywords： control     significant difference     surgical     statistical significance     Sprague-Dawley    

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A mini review: Shape memory polymers for biomedical applications

Kaojin Wang, Satu Strandman, X. X. Zhu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 2,   Pages 143-153 doi: 10.1007/s11705-017-1632-4

Abstract: Shape memory polymers (SMPs) are smart materials that can change their shape in a pre-defined manner under a stimulus. The shape memory functionality has gained considerable interest for biomedical applications, which require materials that are biocompatible and sometimes biodegradable. There is a need for SMPs that are prepared from renewable sources to be used as substitutes for conventional SMPs. In this paper, advances in SMPs based on synthetic monomers and bio-compounds are discussed. Materials designed for biomedical applications are highlighted.

Keywords： shape memory polymer     biodegradability     biocompatibility     biomedical application     bile acids    

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Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 104-111 doi: 10.1007/s11684-017-0568-x

Abstract: Rdh13 is highly expressed in mouse liver, we further evaluated the potential effect of Rdh13 on liver injuryfunctions under regular culture, the mice displayed an attenuated response to CCl -induced liver injuryThis result further implicated Rdh13 as a potential drug target in preventing chemically induced liver injury

Keywords： retinol dehydrogenase 13     carbon tetrachloride     acute liver injury     Cyp2e1     Spot14    

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Title Author Date Type Operation

Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Journal Article

Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones

Zongming Zhang, Zhuo Liu, Limin Liu, Mengmeng Song, Chong Zhang, Hongwei Yu, Baijiang Wan, Mingwen Zhu, Zixu Liu, Hai Deng, Haiming Yuan, Haiyan Yang, Wenping Wei, Yue Zhao

Journal Article

Effects of hydralazine and valproate on the expression of E-cadherin gene and the invasiveness of QBC

Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU

Journal Article

A giant Müllerian duct cyst in the perineum: a case report

Xianghu Meng, Jihong Liu, Xiao Yu, Shaogang Wang, Cong Liu, Zhangqun Ye

Journal Article

Bile acids and their effects on diabetes

Cynthia Rajani, Wei Jia

Journal Article

Diagnosis and treatment of thyroglossal duct carcinoma: Report of three cases with review of literatures

GAO Yan, CHEN Yan, SUN Zhipeng, GUO Chuanbin, YU Guangyan, ZHAN Yi

Journal Article

Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid

Journal Article

Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Journal Article

Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA

Journal Article

Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare

Yong Li,Yuhong Huang,Nan Feng,Heping Zhang,Jing Qu,Shuanggang Ma,Yunbao Liu,Jiang Li,Shaofeng Xu,Ling Wang,Mi Zhang,Jie Cai,Weiping Wang,Ru Feng,Hang Yu,Bo Yu,Dailiang Liang,Heping Qin,Suxiang Luo,Yanfen Li,

Journal Article

Progress and perspectives of neural tissue engineering

Xiaosong Gu

Journal Article

Protective effect of N-acetylcysteine against lipopolysaccharide injury in hepatocytes of neonatal mice

WANG Lin, LIU Yalan, XU Jianbo, TIAN Yuan, WU Heshui

Journal Article

Effect of oxytocin on gastric ischemia-reperfusion injury in rats

ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming

Journal Article

A mini review: Shape memory polymers for biomedical applications

Kaojin Wang, Satu Strandman, X. X. Zhu

Journal Article

Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Journal Article